St. Osanna was a Dominican tertiary, who spent her adult life serving the poor and the sick and offering spiritual direction to many. However, she was also a mystic and a visionary, eventually bearing the pain and red marks of the stigmata, though not the bleeding.

She was born in 1449 to a noble Italian family. Her visions, first of angels and of the Trinity, began at the young age of five. She felt a call to religious life and became a tertiary at 17, having already rejected a marriage arranged by her father.

Her visions continued into her adult life, and she often fell into ecstasies. She was also a strong critic of the lack of morality of her day. She died in 1505.